Exploring the narrow streets of Florence is like strolling through pages of a history book. Il Duomo is the focal point for navigating Florence and a highlight of most visits; its terra-cotta-tiled dome is spectacular, but don’t forget to tour inside to witness the Renaissance masterpiece on the ceiling. Enjoy la dolce vita by sampling local cured meats and artisanal cheeses paired with a Tuscan vino. Florence is best discovered via a small moped, bicycle, or on foot.

City Center.

Without a doubt, the top destination in Florence is the Santa Maria del Fiore or il Duomo; the cathedral is located in the city center—an UNESCO World Heritage Site. This terra-cotta–tiled dome cathedral is one of the largest in the world, bowing to St. Peter’s Basilica in Vatican City. The construction of il Duomo lasted from 1420 to 1436, and today the engineering feat is admired by visitors and locals alike. The cathedral’s creation included valuable contributions from the Renaissance’s most prominent artists—Michelangelo, Donatello, and others.

Entrance into the cathedral is free, but if you want to tour Brunelleschi’s Dome, Giotto’s Bell Tower, the Baptistery of San Giovanni, and the Opera del Duomo Museum, you’ll need tickets. For the adventurous, il Duomo presents a challenge: climbing to the top. It is a tight spiral staircase, but the views are worth every step. Plus, you can reward yourself with tasty Tuscan delights when you return streetside.

Fine Dining.

If Italy is known for one thing, it’s food. Some traditional dishes not to skip are ribollita (a hearty bread, bean, and greens soup); bistecca alla Fiorentina (typically served rare); and lampredotto (offal, yet delicious, sandwich). You can pair all of these with the local, bold red wine, Brunello di Montalcino. A great stop for any foodie and even the pickiest eater is the Mercato Centrale. This market is a combination of food stands with local cheeses, olives, oils, and breads as well as restaurants with plenty of room to sit and enjoy multiple courses. Save room for exceptional desserts, such as Florentine chocolate or zuccotto (a chilled, dome-shaped dessert similar to tiramisu).

Jewel of the Renaissance.

Florence is an art lover’s paradisical visit. Although there are masterpieces of art around every corner and in every piazza, it would be a shame to miss Botticelli’s “Birth of Venus” and da Vinci’s “Annunciation” at the Uffizi Gallery. Those, along with Michelangelo’s “David” in the Galleria dell’Accademia are the classics trifecta in the city of lilies.

Other must-sees, particularly for shutterbugs, are il Porcellino—a bronze wild boar statue that promises good luck for those who rub its snout—and Piazzale Michelangelo for the best panoramic view of it all: il Duomo, Ponte Vecchio (medieval covered bridge), and the Arno River. If you love to shop or just want to pick up a few souvenirs for you or someone special, Florence is famous for its leather craftsmanship (think gloves, jackets, handbags), gold jewelry, and pottery. Head to Mercato Nuovo/Mercato del Porcellino (an open-air market where you can also find the bronze boar) for one-stop souvenir shopping.

Florence has a way of captivating your senses. From the aroma and taste of a glass of Tuscan Brunello to the intricate details of “Birth of Venus,” Florence rekindles an appreciation of natural and manmade beauty. Experience la dolce vita—the sweet life—with a trip to Firenze.

Photography provided by baratroli/iStock/Getty Images Plus, FilippoBacci/E+/Getty Images, samuel howell/iStock/Getty Images Plus, MasterLu/iStock/Getty Images Plus, Shaiith/iStock/Getty Images Plus.